Abstract: BACKGROUND: Sociodemographic data indicate the progressive increase in life expectancy and the prevalence of Alzheimer's disease (AD). AD is raised as one of the greatest public health problems. Its etiology is twofold: on the one hand, non-modifiable factors and on the other, modifiable. OBJECTIVE: This study aims to develop a processing framework based on machine learning (ML) and optimization algorithms to study sociodemographic, clinical, and analytical variables, selecting the best combination among them for an accurate discrimination between controls and subjects with major neurocognitive disorder (MNCD). METHODS: This research is based on an observational-analytical design. Two research groups were established: MNCD group (n = 46) and control group (n = 38). ML and optimization algorithms were employed to automatically diagnose MNCD. RESULTS: Twelve out of 37 variables were identified in the validation set as the most relevant for MNCD diagnosis. Sensitivity of 100%and specificity of 71%were achieved using a Random Forest classifier. CONCLUSION: ML is a potential tool for automatic prediction of MNCD which can be applied to relatively small preclinical and clinical data sets. These results can be interpreted to support the influence of the environment on the development of AD.

Abstract: Surgery is a crucial treatment for malignant brain tumors where gross total resection improves the prognosis. Tissue samples taken during surgery are either subject to a preliminary intraoperative histological analysis, or sent for a full pathological evaluation which can take days or weeks. Whereas a lengthy complete pathological analysis includes an array of techniques to be executed, a preliminary tissue analysis on frozen tissue is performed as quickly as possible (30-45 minutes on average) to provide fast feedback to the surgeon during the surgery. The surgeon uses the information to confirm that the resected tissue is indeed tumor and may, at least in theory, initiate repeated biopsies to help achieve gross total resection. However, due to the total turn-around time of the tissue inspection for repeated analyses, this approach may not be feasible during a single surgery. In this context, intraoperative image-guided techniques can improve the clinical workflow for tumor resection and improve outcome by aiding in the identification and removal of the malignant lesion. Hyperspectral imaging (HSI) is an optical imaging technique with the potential to extract combined spectral-spatial information. By exploiting HSI for human brain-tissue classification in 13 in-vivo hyperspectral images from 9 patients, a brain-tissue classifier is developed. The framework consists of a hybrid 3D-2D CNN-based approach and a band-selection step to enhance the capability of extracting both spectral and spatial information from the hyperspectral images. An overall accuracy of 77% was found when tumor, normal and hyper-vascularized tissue are classified, which clearly outperforms the state-of-the-art approaches (SVM, 2D-CNN). These results may open an attractive future perspective for intraoperative brain-tumor classification using HSI.

Abstract: This paper shows new contributions in the detection of skin cancer, where we present the use of a customized hyperspectral system that captures images in the spectral range from 450 to 950 nm. By choosing a 7 x 7 sub-image of each channel in the hyperspectral image (HSI) and then taking the mean and standard deviation of these sub-images, we were able to make fits of the resulting curves. These fitted curves had certain characteristics, which then served as a basis of classification. The most distinct fit was for the melanoma pigmented skin lesions (PSLs), which is also the most aggressive malignant cancer. Furthermore, we were able to classify the other PSLs in malignant and benign classes. This gives us a rather complete classification method for PSLs with a novel perspective of the classification procedure by exploiting the variability of each channel in the HSI.

Abstract: Hyperspectral images can comprise hundreds of spectral bands, which means that they can represent a large volume of data difficult to manage with the available on-board resources. Lossless compression solutions are interesting for reducing the amount of information stored or transmitted while preserving it at the same time. The Hyperspectral Lossless Compressor for space applications (SHyLoC), which is part of the European Space Agency (ESA) IP core’s library, has been demonstrated to meet the requirements of space missions in terms of compression efficiency, low complexity and high throughput. Currently, there is a trend to use Commercial Off-The-Shelf (COTS) on-board electronic devices on small satellites. Moreover, commercial Field-Programmable Gate Arrays (FPGAs) have been used in a number of them. Hence, a reliability analysis is required to ensure the robustness of the applications to Single Event Upsets (SEUs) in the configuration memory. In this work, we present a reliability analysis of this hyperspectral image compression module as a first step towards the development of ad-hoc fault-tolerant protection techniques for the SHyLoC IP core. The reliability analysis is performed using a fault-injection-based experimental set-up in which a hardware implementation of the Consultative Committee for Space Data Systems (CCSDS) 123.0-B-1 lossless compression standard is tested against configuration memory errors in a Xilinx Zynq XC7Z020 System-on-Chip. The results obtained for unhardened and redundancy-based protected versions of the module are put into perspective in terms of area/power consumption and availability/protection coverage gained to provide insight into the development of more efficient knowledge-based protection schemes.

Abstract: In this paper, we present the design, implementation and results of a set of IP cores that perform on-board hyperspectral image compression according to the CCSDS 123.0-B-1 lossless standard, specifically designed to be suited for on-board systems and for any kind of hyperspectral sensor. As entropy coder, the sample-adaptive entropy coder defined in the 123.0-B-1 standard or the low-complexity block-adaptive encoder defined by the CCSDS 121.0-B-2 lossless standard could be used. Both IPs, 123.0-B-1 and 121.0-B-2, are part of SHyLoC 2.0, and can be used together for compression of hyperspectral images, being also possible the compression of any kind of data using only the 121-IP. SHyLoC 2.0 improves and extends the capabilities of SHyLoC 1.0, currently available at the ESA IP Cores library, increasing its compression efficiency and throughput, without compromising the resources footprint. Moreover, it incorporates new features, such as the unit-delay predictor option defined by the CCSDS 121.0-B-2 standard, and burst capabilities in the external memory interface of the CCSDS 123-IP, among others. Dedicated architectures have been designed for all the possible input image sample arrangements, in order to maximise throughput and reduce the hardware resources utilization. The design is technology-agnostic, enabling the mapping of the VHDL code in different FPGAs or ASICs. Results are presented for a representative group of well-known space-qualified FPGAs, including the new NanoXplore BRAVE family. A maximum throughput of 150 MSamples/s is obtained for Xilinx Virtex XQR5VFX130 when the SHyLoC 2.0 CCSDS-123 IP is configured in Band-Interleaved by Pixel (BIP) order, using only the 4% of LUTs and less than the 1% of internal memory.